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New HPTLC Chapter Proposed for The International Pharmacopoeia
Recommendation
20/21 January 2027
Ensuring Control of Chromatographs, Integration and Results
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The World Health Organization (WHO) has published a draft proposal for a new general chapter "1.18 High-Performance Thin-Layer Chromatography" (HPTLC) to be included in The International Pharmacopoeia.
According to the chapter’s introduction, HPTLC is a chromatographic technique "in which variables are controlled within narrow ranges, using a standardized methodology and appropriate equipment, in order to achieve more reproducible results compared to traditional thin-layer chromatography (TLC)."
The chapter includes:
- An introduction to HPTLC principles
- Required equipment and materials
- A step-by-step analytical procedure
- System suitability criteria and documentation standards
- A new reagent specification (saturated MgCl2 solution)
The draft is currently open for public consultation. Comments can be submitted via the WHO PleaseReview™ platform until 09 September 2025.
The proposed chapter is available on the WHO website under “Working documents in public consultation”.
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